The Bryans are hoping to win their first Grand Slam championship in three years, since raising the 2014 US Open trophy. The 39-year-old twins are currently fifth in the Emirates ATP Doubles Race To London, having finished runners-up at the Australian Open and won titles in Eastbourne and Atlanta.
The Bryans will face 11th-seeded Spaniards Feliciano Lopez and Marc Lopez, who were 6-4, 7-5 winners over Robin Haase and Matwe Middelkoop. Lopez and Lopez are looking to win their second Grand Slam championship together, following victory at Roland Garros last year.
Top seeds Henri Kontinen and John Peers booked their semi-final spot with a 6-3, 6-4 victory over Nicholas Monroe and John-Patrick Smith. The victory comes one day after Kontinen and Peers became the second team to qualify for the Nitto ATP Finals in London at the end of the year.
The Finnish/Australian duo, who won the year-end championships at The O2 last year, are chasing their second major title of the season after lifting the trophy at the Australian Open in January (d. Bryans).
Kontinen and Peers will challenge Jean-Julien Rojer and Horia Tecau after the 12th seeds upset defending champions Jamie Murray and Bruno Soares 6-1, 6-2 in just 62 minutes. Rojer and Tecau have now claimed eight wins in a row, having come into the US Open on the back of victory at the Winston-Salem Open (d. Peralta/Zeballos) – their third ATP World Tour title of the season.